despite 是介词，表示「尽管……（某不利条件），但仍然……」。关键规则：despite 后直接接名词/名词短语/动名词，不能接 that 从句（不说 despite that...）。若要接从句，需改为 despite the fact that 或换用连词 although / even though。与 in spite of 完全同义，均为介词。
释义
1
prep.尽管；虽然（后接名词/动名词）
Despite facing numerous setbacks, she never gave up on her dream.
尽管面临无数挫折，她从未放弃自己的梦想。
2
prep.不顾；不管（despite the risk/opposition）
The project continued despite strong opposition from local residents.
尽管遭到当地居民的强烈反对，该项目仍继续推进。
语感
despite + 名词/动名词；although + 从句——两者含义相同，结构不同，不能混用
尽管虽然不顾
结构对比：despite + 名词（despite the difficulty）/ 动名词（despite working hard）；although + 主语+谓语从句（although she worked hard）；despite the fact that + 从句（尽管……这一事实）。三者可以互换含义，但结构不可混用。注意：despite 和 in spite of 完全等价，可互换，但 despite 更常用，不需要 of。
陷阱
⚠️despite 不接 that 从句
✗
Despite that he studied hard, he failed the exam.
尽管他认真学习，他还是考试不及格。
despite 是介词，不能直接接 that 从句；需要改为 despite the fact that，或换用连词 although
✓
Despite studying hard, he failed the exam. / Although he studied hard, he failed the exam.
尽管努力学习，他还是考试不及格。
⚠️despite of 是错误用法
✗
Despite of the cold weather, they continued hiking.
尽管天气寒冷，他们仍继续徒步。
despite 本身就有「不管」的意思，不需要加 of；despite of 是错误搭配（in spite of 才有 of）
✓
Despite the cold weather, they continued hiking.
尽管天气寒冷，他们仍继续徒步。
近义辨析
despitevsalthough
despite尽管（介词），后接名词/动名词although尽管（连词），后接主谓从句
Despite the financial crisis, the company maintained its workforce.
尽管遭遇金融危机，该公司仍保持了员工人数。
Although the financial crisis was severe, the company maintained its workforce.
尽管金融危机严峻，该公司仍保持了员工人数。
写作加分
✨ 加分词
替换：even thoughbut
议论文让步段落辩证分析描述逆境中的坚持
普通
Even though there are challenges, technology has improved our lives.
即使有挑战，技术也改善了我们的生活。
加分 ✨
Despite its well-documented drawbacks, technology has undeniably transformed the quality of human life over the past century.
尽管其弊端有据可查，技术在过去一个世纪里无可否认地改变了人类生活质量。
为什么更好：Despite + 名词短语（its well-documented drawbacks）比 even though 更简洁有力，句式更紧凑；undeniably 强调结论的不可争辩性，适合议论文让步后反驳的结构